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. 2021 Jul 9;22(14):7388. doi: 10.3390/ijms22147388

Figure 3.

Figure 3

Impact of CNR1 rs2023239 (CT + CC vs. TT.) on Subjective Effects of Cannabis VAS. Measurements (ranging from Not at all to Extremely (0 to 100)) were collected at different time points during acute cannabis intoxication (0–6 h) of n = 52 subjects, separated by rs2023239 genotype. (A) Maximum values of VAS scores obtained with various questions. Unadjusted maximum VAS question results: I feel a drug effect (p = 0.536), I feel this high (p = 0.591), I feel the drug’s good effects (p = 0.200), I feel the drug’s bad effects (p = 0.290), I like the drug (p = 0.080), I feel a rush (p = 0.193), and It feels like cannabis (p = 0.120). (B) Area under the curve analysis for VAS values collected. Unadjusted mixed-effects model AUC results: I feel a drug effect (p = 0.156), I feel this high (p = 0.082), I feel the drug’s good effects (p = 0.209), I feel the drug’s bad effects (p = 0.334), I like the drug (p = 0.006), I feel a rush (p = 0.071), and It feels like cannabis (p = 0.002). (C,D) Time course of the scoring for the VAS question (C) ‘I like the drug’ and (D) ‘It feels like cannabis’. Unadjusted mixed-effects model time course results of I like the drug and (D) It feels like cannabis. * p < 0.05, CT + CC vs. TT.