Skip to main content
. 2021 Jun 25;12(7):975. doi: 10.3390/genes12070975

Figure 2.

Figure 2

Demonstration of Cre recombinase activity driven by the Osterix-GFP-Cre promoter. Select organ sections of Osterix-Cre-;ROSA26mTmG mice (mTmG; (A–F)) and Osterix-Cre+;ROSA26mTmG mice (Osx-Cre;mTmG; (G–L)) showing fluorescence of membranous tdTomato (mT) in the absence of Cre recombinase activity and membranous EGFP (mG) in the presence of Cre recombinase activity. Widely expressed off-target Cre recombinase was confirmed in the olfactory bulb glomerular layer (G), the intestine (H), and the stomach (I). Sparse off-target Cre recombinase expression was seen in the liver (J) and the lungs (K), designated by arrows. No Cre recombinase activity was present in the heart (L). Scale bars (A,B,G,H) = 200 µm. Scale bars (C,F,I,L) = 100 µm.