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. 2021 Jul 6;22(14):7281. doi: 10.3390/ijms22147281

Figure 3.

Figure 3

Example of cells with abnormal nuclear envelope. (A). MDA-MB-231 and SKBR3 breast cancer cells presenting invaginations, twisted nuclei, and micronuclei (white arrow). (B). The breast epithelial cell line MCF10A enters in Epithelial to Mesenchymal Transition upon treatment with TGFß. Upon transformation, cells present nuclear invagination, the presence of micronuclei (white arrow), or donut-shaped nuclei. (C). Confocal image of TGFß-treated MCF10A cells highlight nuclear blebbing (red arrow) with a rupture in the Lamin B1 network. Cells are stained for Lamin B1 (LMNB1-green) and DNA (dapi-blue). Adapted from Comaills et al. [10].