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Chromosomal instability resulting from nuclear envelope disruption of micronuclei (MN). Defects in nuclear envelope of the micronuclei lead to it collapsing, resulting in defective replication and massive DNA damage. MN collapse is associated with a broad range of chromosomal rearrangements such as chromothripsis, the hyper mutated pattern kataegis, as well as the insertion, deletion, and translocation events. Circular chromosomes (ecDNA) are often associated with chromothripsis.
