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. 2021 Jul 14;22(14):7556. doi: 10.3390/ijms22147556

Figure 4.

Figure 4

HPLC analysis of DA and its turnover rate in dopaminergic structures SN (A) and STR (B). Turnover rate was calculated as sum of measured metabolites to neurotransmitter ratio. Data are presented as mean ± SEM. Analysis was performed at time-points 4 days, 2 weeks, and 4 weeks after brain surgery. Animals were kept on ketogenic diet for 3 weeks in advance. p value ≤ 0.05 was set as significance threshold and marked as * vs. normal diet + sham (NS group), L vs. normal diet + 6-OHDA lesion (NL group), K vs. ketogenic diet + sham (KS group), KL stands for ketogenic diet + 6-OHDA lesion group, 2W vs. 2 week time-point, 4D vs. 4 day time-point. Statistical trends 0.05 < p ≤ 0.1 were marked in grey symbols. Statistics: 3-way ANOVA with LSD post hoc test. Number of animals was 5–7 per group.