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. 2021 Jul 8;22(14):7342. doi: 10.3390/ijms22147342

Figure 2.

Figure 2

CD34+SCs/TCs in normal skin. Double immunochemistry for CD34 (brown) and αSMA (red). (A,B) Absence of interstitial and perivascular CD34+SCs/TCs in the papillary dermis. Note a vessel in (A), in which the perivascular CD34+SCs/TCs are absent as the vessel enters the papillary dermis (arrow). (C) Vessels in the upper horizontal plexus and numerous CD34+SCs/TCs in perivascular and interstitial location. (D,E) The wall of an artery (D) and veins (E) in the plexus located in the dermal subcutaneous junction. Several layers of CD34+SCs/TCs are observed in the arterial adventitia (D, arrowhead) and in smaller numbers around veins (E, arrowhead). Note the presence of cusped valves in the latter (arrows). (F,G) CD34+SCs/TCs (brown) surrounding groups of smooth muscle cells (red) in pre-collector lymphatic vessels, in which the endothelial cells do not express CD34. H: CD34+SCs/TCs around fascicles of arrector pili muscle. Vein (E) and lymphatic (F,G) lumen: lu. Bar: (A,C,F,G,H) 45 µm, (B) 55 µm, (D,E) 80 µm.