Table 2.

A succinct list comprising the most interesting, promising, and already tested nanocarriers used in lung cancer therapy experiments.

Nanocarrier	Carrier Material and Characteristics
Tecemotide	Carrier material: Synthetic lipopeptide Found under the form of liposomes, actively targets MUC1 tumor-associated antigen (TAA), aberrantly expressed by over 90% in lung cancers, well-tolerated by the human body, but low or imperceptible efficacy [174,175]
ExtraCRAd	Carrier material: Biohybrid viral nanoparticle Consists of an oncolytic virus artificially encapsulated in tumor cancer membranes carrying tumor antigens, preliminary results involving it showed indisputable tumor control in murine models of lung cancer and melanoma [176]
HVJ-E	Carrier material: Viral envelope Represents the hemagglutinating virus of Japan envelope (HJ-E) obtained from the replication-deficient Sendai virus, actively targets ICAM-1, largely present in lung cancer, very promising drug delivery agent, considering that it already has thoroughly proven direct oncolytic effects, proven to be suitable as a gene delivery system [177,178,179,180]
Bacterial-derived minicells	Carrier material: Bacterially derived nano-sized particles Can be loaded with a wide range of various chemotherapeutic agents, coating them with specific, customized antibodies will result in a very high tumoral specificity, showed enhanced biodistribution to the lungs, while carrying doxycycline [181,182]
Polymeric nanoparticles	Carrier material: Polymer-based nanoparticles or lipid-polymer hybrid nanoparticles Particles may be co-decorated with Nitroimidazoles (NI) to improve the targeting of the hypoxic tumoral environment and/or Hyaluronic acid (HA) to improve (lung) tumoral targeting even more by binding to the CD44 cell marker, and such carriers loaded with cisplatin showed an impressive tolerability and promising results for prospective lung cancer treatment [183,184]