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. 2021 Jul 2;10(7):1664. doi: 10.3390/cells10071664

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Astrocytic Differentiation Could be altered by 660-nanometer LED Irradiation (Oct4 co-expression). (A,C) Representative images of immunofluorescence staining (scale bar: 50 μm); (A) The white arrow denotes GFAP− and Oct4 co-expressing cells, which were significantly decreased by 660-nanometer LED irradiation; (C) The yellow arrow denotes aldh1L1− and Oct4 co-expressing cells; (B,D) The graph of protein expression was shown. Compared to the control, 660-nanometer LED irradiation significantly decreased GFAP+/Oct4+ cell expression (n = 35, * p < 0.05) and aldh1L1+/Oct4 showed only a decreased tendency.