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. 2021 Jul 16;118(29):e2105803118. doi: 10.1073/pnas.2105803118

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Copyright © 2021 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).

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Fig. 3. — Effects on lymphoid tissue and viral activity. Lymph nodes were biopsied from n = 19 macaques at day 14 of isolated and juvenile-partnered SIP and assessed for (A) expression of proinflammatory and Type I IFN response genes, (B) RNA sequencing–based bioinformatic indications of change IFN-related (IRF, STAT, GFI) and neuroendocrine-related (GR, CREB) transcription factors (TFs), and (C) metagenomic sequence analysis of viral and metazoan (host/macaque) transcript abundance. (D) Parallel metagenomic sequence analysis of viral and metazoan (host/macaque) transcript abundance in PBMC. Values: mean ± SE; P values: mixed effect linear model SIP mode effect; *P < 0.05, **P < 0.01.