Figure 3.

Correlation between HLA-I/PD-L1 tumor phenotype and lymphocyte infiltration (A), tumor encapsulation (B), and tumor grade (C). T-cell exclusion (encapsulated) pattern is typical for HLA-I negative tumors with potentially immunoresistant phenotypes HLA-I-/PD-L1- and HLA-I/-PD-L1+ and an increased presence of FAP-positive stroma cells. Tumors with a diffuse stromal pattern and low FAP expression are mostly positive for HLA-I. C) The majority of high grade tumors are HLA-I negative independently of the PD-L1 status. p-values were obtained using chi-square test with IBM SPSS Statistics Ver.21.0 software. Differences between different groups were considered statistically significant at p < 0.05.