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. 2021 Jul 15;22(14):7587. doi: 10.3390/ijms22147587

Figure 2.

Figure 2

DMRs are associated with promoters and enhancers. Relative quantities of hyper- and hypo-DMRs that overlap with promoters (A), enhancers (D), and super-enhancers (E). (B) The relation between fold change of gene expression and the changes in DNA methylation within DMR in promoter regions. Hexagon plot showing methylation level for CpGs: (C) in all promoters (n = 1,514,345), in upregulated in Kaiso KO cells (n = 505,656), in downregulated in Kaiso KO cells (n = 32,328); (D) in enhancers (n = 254,090) with (n = 10,551) or without H3K27ac (n = 243,539); (E) in super-enhancers (n = 213,561) with (n = 162,969) or without H3K27ac (n = 50,592).