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. 2021 Jul 16;22(14):7640. doi: 10.3390/ijms22147640

Figure 2.

Figure 2

Degranulation and chemokine expression in hiMC following treatment with stattic, nobiletin, and resveratrol. Release of β-hexosaminidase (A) (n = 9) and mRNA expression of Cxcl8 (B) (n = 4), Ccl2 (C) (n = 3), Ccl3 (D) (n = 3), Ccl4 (E) (n = 3), and Tnf-α (F) (n = 3) by hiMC following treatment with 60 μM of stattic (S), 45 μM of nobiletin (N), or 50 μM of resveratrol (R), or corresponding concentrations of the vehicle DMSO (control). Cells were stimulated by FcεRI crosslinking using 100 ng/mL of mAb 22E7 for 5–90 min (A) and 90 min (B–F). Results are shown in % of stimulated control. Values are mean ± SEM. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.