Table 2.
Roles of domains with known cellular functions in mediating specific BRCA2 functions in DNA damage responses.
| Specific BRCA2 Function | PALB2-Binding Domain | BRC Repeats | C-Terminal DNA Binding Domain | C-Terminal RAD51-Binding Domain | NLS- 1, 2 and 3 |
|---|---|---|---|---|---|
| BRCA2 Foci | + [8] |
||||
| RAD51 Foci | +/− [78] |
+ [8] |
|||
| HR | +/− [46,76,87] |
+/− [78] |
+ [8,81,82,83,84,87] |
− [14,76] |
|
| G2 Checkpoint | |||||
| Replication Fork Protection | + [97] |
− [14] |
+ [14] |
||
| Chromosome Stability | +/− [87,97] |
+/− [87] |
+/− [14] |
||
| Proliferation | + [87] |
+ [87] |
|||
| Resistance to IR | +/− [87] |
+ [8,81] |
|||
| Resistance to Chemotherapeutic Agents and/or MMC | +/− [87] |
+/− [78] |
+ [8,67,81,87] |
− [14] |
+ indicates the domain is required for this particular function; +/− indicates a partial role, typically intermediate between the activity of WT BRCA2 and the empty vector; − indicates the domain was demonstrated to not have a role in this particular function; a blank box indicates that a particular function has not been directly tested for this domain.