Figure 2.

Altered lipid metabolism in GBM promotes cancer properties and interacts with immune cells. Alterations in lipid metabolism in GBM cells causes an increased production of GD2, which increases motility, invasiveness, and proliferation of GBM cells, as well as GD3, which is involved in the maintenance of glioma stem cell properties and can induce T cell apoptosis. Additional lipids shed from GBM cells can drain to the periphery, where they can act as antigens and stimulate antibody production. Lipid antigens derived from GBM cells can also be presented to NKT cells in the context of CD1d.