Figure 3.

Cellular distribution of TG2 multiple functions and cell types involved in tissue injury processes. Enzymatic activities such as crosslinking, amine incorporation including hypusine and serotonin, GTPase/ATPase, PDI, and kinase as well as non-enzymatic adapter/scaffold activities are shown for TG2 localized in the nucleus, cytosol, underneath the plasma membrane, and in the extracellular compartment. TG2 functions in macrophage engulfment and tissue repair events following cell death induction are also demonstrated.