Table 3.
Combination of serum exosomal protein markers and AFP in HCC diagnosis.
| HCC vs. Non-Tumor (Normal, CHB, and LC) | ||||||||
|---|---|---|---|---|---|---|---|---|
| p vs. AFP | Cut-Off | AUC | 95% CI | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | |
| AFP + CCT8 | 0.169 | 0.6106 | 0.728 | 0.664–0.785 | 46.21 | 93.48 | 91.05 | 54.77 |
| AFP + CFL1 | 0.444 | 0.4704 | 0.773 | 0.712–0.826 | 75.76 | 67.39 | 76.92 | 65.96 |
| CCT8 + CFL1 | 0.045 | 0.4434 | 0.829 | 0.773–0.876 | 85.61 | 61.96 | 76.35 | 75.00 |
| AFP + CCT8 + CFL1 | 0.027 | 0.5438 | 0.838 | 0.783–0.884 | 70.46 | 81.52 | 84.55 | 65.79 |
HCC, hepatocellular carcinoma; CHB, chronic hepatitis B; LC, liver cirrhosis; AFP, alpha-fetoprotein; CCT8, chaperonin-containing TCP1 subunit 8; CFL1, cofilin 1; AUC, area under the curve; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value.