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. 2021 Jul 8;10(14):3039. doi: 10.3390/jcm10143039

Figure 4.

Figure 4

Genes and AKI susceptibility relationship. A red color pinpoints the genes associated with AKI, in which a dark red color highlights a strong association, while a light red color indicates a weak association. No association is marked by a green color. Genes are presented according to the mechanism involved in AKI pathogenesis. Abbreviations: ACE, angiotensin-converting enzyme gene; AGT, angiotensinogen gene; APOE, apolipoprotein E gene; BCL-2, B-cell CLL/lymphoma 2 gene; BBS9, Bardet–Biedl syndrome 9 gene; CAT, catalase gene; COMT, catechol-O-methyltransferase gene; eNOS, endothelial nitric oxide synthase gene; EPO, erythropoietin gene; HIF1-α, hypoxia-inducible factor 1-α gene; HLA-DRB1, human leukocyte antigen–major histocompatibility complex, class II, DR beta 1 gene; IFN-γ, interferon-γ gene; IL-6, interleukin-6 gene; IL-18, interleukin-18 gene; IL-10, interleukin-10 gene; MIF, macrophage migration inhibitory factor gene; MPO, myeloperoxidase gene; NADPH, nicotinamide adenosine dinucleotide phosphate gene; NFκB, nuclear factor-κB gene; PHLPP2, PH domain and leucine-rich repeat protein phosphatase 2 gene; PNMT, phenylethanolamine N-methyltransferase gene; SERPINA, serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin) gene; SIK3, salt-inducible kinase 3 gene; SP-D, surfactant protein-D gene; STAT3, transducer and activator of transcription 3 gene; SUFU, suppressor of fused homolog gene; TGF-β, transient growth factor-β gene; TNF-α, tumor necrosis factor α gene; VEGF, vascular endothelial growth factor gene.