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Cannabinoid-mediated impact on monoamine signaling in the brain. Cannabinoid-mediated stimulation of CB1 receptors on monoaminergic neurons leads to delayed transport of monoamines to the synapse, decreasing monoamines in the synapse. Abbreviations: GABA, gamma aminobutyric acid; Glu, glutamate; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; NMDA, N-methyl-D-aspartate; CB1, cannabinoid-1 receptor.
