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Impact following tetrahydrocannabinol/cannabidiol administration on in vitro CYP enzyme activity [30].
| IC50µ (µM) 1 | ||
|---|---|---|
| CBD | THC | |
| CYP2C19 | 0.30 ± 0.03 | 0.57 ± 0.22 |
| CYP2D6 | 0.95 ± 0.50 | 1.28 ± 0.25 |
| CYP3A4 | 0.38 ± 0.11 | 1.30 ± 0.34 |
1 CBD, cannabidiol; THC, tetrahydrocannabinol; IC50µ, binding-corrected 50% inhibitory concentration.
