Table 5.
Changes in patient serum biochemical parameters during the trial, and comparison between groups.
| Variables | Control Group | Experimental Group | Between Groups | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T0 | T1 | T2 | Difference | T0 | T1 | T2 | Difference | T0 | T1 | T2 | Difference | ||||||||
| T0–T1 | T0–T2 | T0–T1 | T0–T2 | T0–T1 | T0–T2 | ||||||||||||||
| Median (25th–75th) Percentile |
P a | Median (25th–75th) Percentile |
P b | Median (25th–75th) Percentile |
P a | Median (25th–75th) Percentile |
P b | P c | P c | P c | P c | P c | |||||||
| Glucose (mg/dL) |
101.8 (95.5–118.9) |
100.0 (91.9–108.1) |
88.2 (82.8–102.7) |
0.021 | 4.5 (−3.6–12.6) |
9.0 (1.8–18.0) |
0.240 | 118.9 (100.9–149.5) |
112.6 (106.3–131.5) |
125.2 (111.7–142.3) |
0.084 | 10.8 (−5.4–12.6) |
−9.0 (−14.4–10.8) |
0.334 | 0.057 | 0.005 | <0.001 | 0.466 | 0.103 |
| Creatinine (mg/dL) |
0.799 (0.738–0.878) |
0.770 (0.717–0.937) |
0.797 (0.760–0.816) |
0.678 | −0.016 (−0.137–0.086) |
0.008 (−0.072–0.094)) |
0.557 | 0.850 (0.767–0.952) |
0.883 (0.791–1.078) |
0.852 (0.772–0.912) |
0.128 | −0.052 (−0.180–0.027) |
−0.018 (−0.053–0.085) |
0.028 | 0.275 | 0.048 | 0.071 | 0.384 | 0.987 |
| Urea (mg/dL) |
39.1 (33.5–51.8) |
38.9 (32.8–47.2) |
42.5 (34.9–49.0) |
0.167 | 3.8 (−5.5–8.5) |
−2.8 (−9.6–2.5) |
0.227 | 46.1 (35.3–51.6) |
53.5 (37.4–85.2) |
46.9 (41.9–59.3) |
0.042 | −10.9 (−32.4– –1.6) |
−5.8 (−16.0–8.5) |
0.035 | 0.477 | 0.008 | 0.150 | 0.003 | 0.764 |
| LDH (U/L) |
136.8 (107.8–160.0) |
134.0 (104.1–150.8) |
143.7 (125.6–153.9) |
0.358 | 7.2 (−19.3–32.9) |
−3.9 (−18.6–6.1) |
0.071 | 131.3 (116.1–157.8) |
124.9 (98.7–137.9) |
138.6 (124.1–152.3) |
0.115 | 11.8 (−1.4–32.9) |
−11.9 (−25.1–18.9) |
0.025 | 0.812 | 0.578 | 0.800 | 0.411 | 0.888 |
| CPK (U/L) |
77.7 (66.7–106.4) |
78.4 (59.2–93.1) |
75.3 (61.8–97.9) |
0.801 | −1.2 (−38.4–23.1) |
1.9 (−4.8–43.2) |
0.679 | 80.9 (65.4–96.3) |
89.2 (55.2–119.0) |
85.3 (56.0–113.6) |
0.678 | −4.0 (−51.2–6.3) |
1.2 (−27.6–32.1) |
0.396 | 0.912 | 0.602 | 0.402 | 0.384 | 0.477 |
| AlkPhos (U/L) |
99.3 (83.8–108.5) |
95.6 (86.6–103.0) |
96.5 (94.6–98.8) |
0.678 | 2.0 (−2.2–9.2) |
1.8 (−9.1–10.0) |
0.349 | 80.7 (71.0–96.9) |
90.2 (83.8–101.6) |
86.0 (79.0–105.1) |
0.066 | −4.1 (−13.8–0.7) |
−4.7 (−30.4–0.2) |
0.500 | 0.094 | 0.558 | 0.141 | 0.031 | 0.052 |
| GGTP (U/L) |
21.7 (13.4–38.0) |
18.2 (13.2–33.1) |
26.0 (15.6–60.3) |
0.486 | 1.8 (−1.3–5.3) |
−1.5 (−7.8–3.1) |
0.231 | 20.6 (16.4–30.8) |
19.6 (15.7–26.6) |
24.1 (16.6–31.4) |
0.211 | 2.0 (−0.3–4.2) |
0.0 (−2.7–2.9) |
0.151 | 0.888 | 0.728 | 0.517 | 0.558 | 0.692 |
| AST (U/L) |
20.6 (15.6–24.1) |
21.0 (16.0–24.0) |
18.2 (16.2–21.7) |
0.946 | 1.1 (−2.1–3.6) |
−0.6 (−2.7–3.2) |
0.862 | 18.5 (15.1–24.0) |
19.7 (15.8–24.7) |
19.2 (15.4–22.5) |
0.577 | −0.4 (−2.2–1.5) |
−0.2 (−4.0–2.5) |
0.500 | 0.624 | 0.862 | 0.602 | 0.467 | 0.924 |
| ALT (U/L) |
17.7 (10.2–23.7) |
15.4 (11.2–32.0) |
20.4 (13.2–29.8) |
0.607 | –0.9 (−6.6–5.0) |
−2.2 (−11.2–5.7) |
0.647 | 13.6 (10.5–16.9) |
13.6 (9.7–19.8) |
12.1 (9.3–20.1) |
0.678 | −1.6 (−5.5–4.8) |
−2.0 (−5.5–2.9) |
0.913 | 0.235 | 0.319 | 0.154 | 0.937 | 0.987 |
| De Ritis ratio (rel. un.) |
1.24 (1.01–1.46) |
1.28 (0.72–1.70) |
0.96 (0.74–1.31) |
0.311 | 0,10 (−0.46–0.46) |
0.26 (−0.46–0.48) |
0.184 | 1.34 (1.08–2.13) |
1.42 (0.85–2.37) |
1.43 (0.99–1.61) |
0.846 | −0.09 −0.79–0.73) |
0.22 (−0.35–0.74) |
0.616 | 0.261 | 0.223 | 0.133 | 0.937 | 0.837 |
a—based on a Freidman ANOVA, b—based on a two-tailed Wilcoxon test, c—based on a two-tailed Mann–Whitney U test.