Figure 1.

Dose-dependence and time-dependence of cell metabolic activity. HUVEC were cultured 2 h (a) or 24 h (b) with different concentrations of total polyphenols contained (TPC) in Rosso di Pitigliano (RED) tomato peel extracts (5-20-50-100 µg GAE/mL), which are obtained under normal plant growing conditions (Ctr) or in dehydration conditions (Ds). Data are expressed as % of metabolically active cells on an untreated cell basis (control). Graphical data are represented as mean ± SD of three separate experiments run in triplicate. * p < 0.05, ** p < 0.005, *** p < 0.0001 vs. Control (untreated cells).