Table 3.
Cyclodextrin-based supramolecular hydrogels for gene therapy.
| Hydrogel | Vector | Drug | In Vitro | In Vivo | References |
|---|---|---|---|---|---|
| PEG-α-CD/CD PPRX | pDNA | - | Colon-26 | Male Balb/C mice | [140] |
| PF68-PLL/α-CD | pDNA | - | mouse fibroblast cells 3T3 | - | [141] |
| MPEG-PCL-PDMAEMA/α-CD | pDNA | - | COS-7 | - | [142] |
| MPEG-PLLD-Arg/α-CD | pMMP-9 | - | HNE-1 | Nude mice bearing HNE-1 tumors | [143] |
| MPEG-PCL-PEI-FA/α-CD | pDNA-Nur77 | Paclitaxel | HEK293 H460 | Male Balb/C nude mice, tumor model | [144] |
Abbreviations: PEG: poly(ethylene glycol); α-CD: α-Cyclodextrin; CD: cyclodextrins; PPRX: polypseudorotaxanes; PF68: Pluronic F-68; PLL: poly(L-lysine); MPEG: methoxy-poly(ethylene glycol); PCL: poly(ε-caprolactone); PDMAEMA: poly(2-(dimethylamino)ethyl methacrylate); PLLD-Arg: arginine-functionalized poly(L-lysine) dendron; PEI: poly(ethylene imine); FA: folic acid; pDNA: plasmid DNA; Nur 77: Bcl-2 (B-cell lymphoma 2) conversion Nur77 gene; pMMP-9: MMP-9 shRNA plasmid (MMP—matrix metallopeptidase; shRNA: short-hairpin RNA); HNE-1: human nasopharyngeal carcinoma.