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. 2021 Jul 14;13(14):3520. doi: 10.3390/cancers13143520

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Regulatory effects network. The above upstream regulator effects network was predicted by the IPA bioinformatic analysis of the 191 DE proteins elevated in metastasizing pUM. Symbols: circle, complex/group; square—cytokine; vertical oval—transmembrane receptor; horizontal oval—transcription regulator; trapezoid—transporter. Solid lines represent direct interactions; dashed lines represent indirect interactions. IPA predicted no regulatory effects network for DE proteins elevated in non-metastasizing pUM.