Table 2.

Differentially Expressed pUM Proteins.

UniProt Accession	Gene Name	Protein (Sorted by Decreasing Protein Ratio)	Protein Ratio Met/NoMet	Adjusted p-Value	Frequency
					Metastasizing pUM	Non-Metastasizing pUM
DE Proteins Most Abundant in Metastasizing pUM
P23381	WARS1	Tryptophan--tRNA ligase, cytoplasmic	1.906	4.6 × 10−6	53	47
P04439	HLA-A	HLA class I histocompatibility antigen, A alpha chain	1.818	1.6 × 10−6	53	47
P61769	B2M	Beta-2-microglobulin	1.768	2.7 × 10−5	47	39
P01903	HLA-DRA	HLA class II histocompatibility antigen, DR alpha chain	1.727	9.2 × 10−5	53	47
Q03518	TAP1	Antigen peptide transporter 1	1.630	3.2 × 10−5	53	47
P10321	HLA-C	HLA class I histocompatibility antigen, C alpha chain	1.624	1.8 × 10−5	52	46
Q8IVF2	AHNAK2	Protein AHNAK2	1.616	8.8 × 10−4	44	36
O95816	BAG2	BAG family molecular chaperone regulator 2	1.595	2.3 × 10−7	42	39
P07686	HEXB	Beta-hexosaminidase subunit beta	1.589	1.9 × 10−4	53	47
P33121	ACSL1	Long-chain-fatty-acid--CoA ligase 1	1.562	1.4 × 10−5	53	47
P17931	LGALS3	Galectin-3	1.549	4.6 × 10−5	52	47
P19971	TYMP	Thymidine phosphorylase	1.534	9.4 × 10−4	53	47
P51810	GPR143	G-protein coupled receptor 143	1.530	4.6 × 10−4	53	47
Q06210	GFPT1	Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1	1.505	3.8 × 10−5	53	47
Q9H3G5	CPVL	Probable serine carboxypeptidase CPVL	1.486	7.4 × 10−4	53	47
DE Proteins Least Abundant in Metastasizing pUM
P04792	HSPB1	Heat shock protein beta-1	0.726	1.4 × 10−5	53	47
Q9UBI6	GNG12	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	0.722	1.6 × 10−3	45	40
Q9BZQ8	NIBAN1	Protein Niban 1	0.720	1.2 × 10−3	53	47
Q8NC51	SERBP1	Plasminogen activator inhibitor 1 RNA-binding protein	0.718	1.6 × 10−2	53	47
P28161	GSTM2	Glutathione S-transferase Mu 2	0.710	5.4 × 10−4	53	47
Q9P0M6	MACROH2A2	Core histone macro-H2A.2	0.708	1.1 × 10−5	47	39
Q9NUJ1	ABHD10	Mycophenolic acid acyl-glucuronide esterase, mitochondrial	0.707	6.8 × 10−7	53	47
Q14240	EIF4A2	Eukaryotic initiation factor 4A-II	0.697	2.3 × 10−7	53	47
P05387	RPLP2	60S acidic ribosomal protein P2	0.697	4.1 × 10−5	53	47
P34913	EPHX2	Bifunctional epoxide hydrolase 2	0.688	8.4 × 10−5	53	47
Q02252	ALDH6A1	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	0.681	1.3 × 10−6	53	47
P21266	GSTM3	Glutathione S-transferase Mu 3	0.676	2.6 × 10−3	53	47
P09211	GSTP1	Glutathione S-transferase P	0.673	5.5 × 10−3	53	47
Q02338	BDH1	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	0.672	1.4 × 10−5	50	44
O75891	ALDH1L1	Cytosolic 10-formyltetrahydrofolate dehydrogenase	0.604	4.6 × 10−6	46	42

The above proteins were selected from 402 total differentially expresssed (DE) proteins identified by LC MS/MS iTRAQ technology (see Supplementary Table S6). Note that the protein ratio is expressed as metastasizing pUM (Met)/non-metastasizing pUM (noMet); DE proteins least abundant in metastasizing pUM are most abundant in non-metastasizing pUM.