Table 3.
Selected Proteins in the Final Prediction Model for UM Metastasis.
| Uniprot Accession | Gene Nmae | Protein | Regression Coefficients | Odds Ratio | Protein Ratio Met/NoMet | Cell Surface Localization |
|---|---|---|---|---|---|---|
| P04439 | HLA-A | HLA class I histocompatibility antigen, A alpha chain | 0.436 | 1.547 | 1.818 | X |
| Q86UX7 | FERMT3 | Fermitin family homolog 3 | 0.028 | 1.029 | 1.419 | |
| P04062 | GBA | Lysosomal acid glucosylceramidase | 0.499 | 1.647 | 1.412 | |
| P67936 | TPM4 | Tropomyosin alpha-4 chain | 0.061 | 1.063 | 1.330 | |
| P21796 | VDAC1 | Voltage-dependent anion-selective channel protein 1 | 0.546 | 1.727 | 1.225 | X |
| A0FGR8 | ESYT2 | Extended synaptotagmin-2 | 0.497 | 1.643 | 1.216 | X |
| P13674 | P4HA1 | Prolyl 4-hydroxylase subunit alpha-1 | −0.310 | 0.733 | 1.211 | |
| P23368 | ME2 | NAD-dependent malic enzyme, mitochondrial | 0.050 | 1.051 | 1.201 | |
| Q15056 | EIF4H | Eukaryotic translation initiation factor 4H | 0.702 | 2.017 | 1.190 | |
| P50570 | DNM2 | Dynamin-2 | 0.131 | 1.140 | 1.175 | X |
| Q99829 | CPNE1 | Copine-1 | 0.072 | 1.075 | 1.174 | X |
| Q9HD67 | MYO10 | Unconventional myosin-X | 0.252 | 1.287 | 1.160 | X |
| P49748 | ACADVL | Very long-chain specific acyl-CoA dehydrogenase, mitochondrial | 0.072 | 1.075 | 1.154 | |
| Q00341 | HDLBP | Vigilin | 0.485 | 1.623 | 1.122 | X |
| P48729 | CSNK1A1 | Casein kinase I isoform alpha | 0.030 | 1.031 | 1.121 | |
| P53621 | COPA | Coatomer subunit alpha | 0.490 | 1.632 | 1.116 | |
| P11142 | HSPA8 | Heat shock cognate 71 kDa protein | 0.018 | 1.018 | 1.096 | X |
| P54920 | NAPA | Alpha-soluble NSF attachment protein | 0.050 | 1.051 | 1.095 | X |
| Q13616 | CUL1 | Cullin-1 | −0.178 | 0.837 | 0.903 | X |
| Q9BPX5 | ARPC5L | Actin-related protein 2/3 complex subunit 5-like protein | −0.102 | 0.903 | 0.895 | |
| P38606 | ATP6V1A | V-type proton ATPase catalytic subunit A | −0.124 | 0.883 | 0.885 | X |
| Q9BR76 | CORO1B | Coronin-1B | −0.110 | 0.896 | 0.874 | X |
| Q96TA1 | NIBAN2 | Protein Niban 2 | −0.448 | 0.639 | 0.864 | X |
| Q14344 | GNA13 | Guanine nucleotide-binding protein subunit alpha-13 | −0.213 | 0.808 | 0.844 | X |
| P01024 | C3 | Complement C3 | −0.124 | 0.883 | 0.840 | X |
| Q8N1G4 | LRRC47 | Leucine-rich repeat-containing protein 47 | −0.391 | 0.677 | 0.838 | |
| Q14624 | ITIH4 | Inter-alpha-trypsin inhibitor heavy chain H4 | −0.380 | 0.684 | 0.836 | X |
| Q9NXF1 | TEX10 | Testis-expressed protein 10 | −0.512 | 0.599 | 0.802 | |
| P62899 | RPL31 | 60S ribosomal protein L31 | −0.094 | 0.911 | 0.795 | |
| Q96I99 | SUCLG2 | Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial | −0.254 | 0.775 | 0.789 | X |
| Q9BZQ8 | NIBAN1 | Protein Niban 1 | −0.095 | 0.910 | 0.720 | X |
| P28161 | GSTM2 | Glutathione S-transferase Mu 2 | −0.171 | 0.843 | 0.710 |
The above 32 protein prediction model for UM metastasis was generated with the LASSO modeling method and provided 93% discriminatory accuracy based on the AUC of the ROC curve in Figure 6. Cell surface localization reflects GO analysis prediction results for plasma membrane proteins.