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Pragmatic approach to diagnosis and treatment of TMA. Patients should be tested for the enzymatic activity of ADAMTS13 (i.e., >10% excludes thrombotic thrombocytopenic purpura (TTP)). Patients with a normal activity of ADAMTS13 should be screened for coexisting conditions. DGKE, diacylglycerol kinase epsilon. HSCT, hematopoietic stem cell transplantation. HUS, hemolytic uremic syndrome. STEC, Shiga toxin–producing E. coli.
