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. 2021 Jul 8;10(14):3034. doi: 10.3390/jcm10143034

Figure 4.

Figure 4

Morphologic features of TMA on kidney biopsy cannot define etiology. Representative cases of TMA presenting with coexisting hypertensive emergency: (A) 28-year-old woman with a gain-of-function C3 protein (p.R161W); (B) 47-year-old man with no rare variants in complement genes identified, after surgery; (C) 37-year-old woman with no rare variants in complement genes identified, and coexisting pregnancy; (D) 28-year-old woman with no rare variants in complement genes identified. The arrowheads indicate glomerular thrombosis, often accompanied by mesangiolysis. Jones methenamine silver (A–C) and hematoxylin and eosin (D) staining; original magnification, ×400.