Table 2.
Upregulated DEGs in NCI-H520 and NCI-H23 cells in response to MS13 treatment.
| Genes/Cell Line | Gene Description | Accession No. | Single/Multiple Pathways | FC | p-Value |
|---|---|---|---|---|---|
| NCI-H520 | |||||
| PTEN | Phosphatase and Tensin Homolog | NM_000314.3:1675 | PI3K | 1.3 | 0.0233 |
| DDIT4 | DNA Damage Inducible Transcript 4 | NM_019058.2:85 | PI3K | 1.4 | 0.0223 |
| ENDOG | Endonuclease G | NM_004435.2:694 | Cell-cycle Apoptosis | 1.5 | 0.00367 |
| CASP8 | Caspase 8 | NM_001228.4:301 | Cell-cycle Apoptosis | 1.4 | 0.0341 |
| DDIT3 | DNA Damage Inducible Transcript 3 | NM_004083.4:40 | MAPK | 1.3 | 0.00325 |
| CDKN1A | Cyclin Dependent Kinase Inhibitor 1A | NM_000389.2:1975 | Cell-cycle Apoptosis and PI3K | 2.1 | 0.0006 |
| * CCND3 | Cyclin D3 | NM_001760.2:1215 | Cell-cycle Apoptosis and PI3K | 1.4 | 0.015 |
| GADD45G | Growth Arrest and DNA Damage Inducible Gamma | NM_006705.3:250 | Cell-cycle Apoptosis and MAPK | 2.1 | 0.000258 |
| NCI-H23 | |||||
| ITGA2 | Integrin Subunit Alpha 2 | NM_002203.2:475 | PI3K | 1.4 | 0.00405 |
| THEM4 | Thioesterase Superfamily Member 4 | NM_053055.4:764 | PI3K | 1.3 | 0.00716 |
| TNFRSF10A | TNF Receptor Superfamily Member 10a | NM_003840.3:2380 | Cell-cycle Apoptosis | 1.4 | 0.00918 |
| IRAK2 | Interleukin 1 Receptor Associated Kinase 2 | NM_001570.3:1285 | Cell-cycle Apoptosis | 1.4 | 0.00186 |
| DUSP2 | Dual Specificity Phosphatase 2 | NM_004418.3:1235 | MAPK | 1.3 | 0.0344 |
| * CCND3 | Cyclin D3 | NM_001760.2:1215 | Cell-cycle Apoptosis and PI3K | 1.3 | 0.00733 |
* Indicates mutually expressed DEGs in both NCI-H520 and NCI-H23 cells treated with MS13.