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Epidermal growth factor receptor (EGFR) controls cell growth via Akt signaling. Akt signaling activates hypoxia-inducing factor 1α (HIF-1α) and forkhead box O3 (FOXO3)/ nuclear receptor subfamily 1 group H member 3 (LXRα) to produce a growth signal. Likewise, Akt stimulates nuclear factor kappa B (NF-κB) followed by secreted phospholipase A2-IIa (sPLA2-IIA), which reciprocally reinforces EGFR signaling. A black arrow represents signal transduction; a red arrow represents cell fate.
