Table 2.
Serum levels of different biomarkers.
| Median (Range) | mCRPC V1–V6 | PCa-l | V1 | p-Value |
|---|---|---|---|---|
| V2 + V3 | ||||
| CD44 (pg/mL) | 710 (205.9–4878) | 777.1 (230.6–3382) | 783.6 (386–2440) | 0.70 |
| DKK-1 (pg/mL) | 4625 (566.9–8878) | 3939 (1632–10937) | 3976 (1273–7988) | 0.80 |
| sHer2 (ng/mL) | 3.3 (0.83–16.46) | 3.3 (1.1–7.7) | 3.5 (1.27–8.4) | 0.39 |
| IL-6 (pg/mL) | 11.7 (1.91–180) | 5.6 (1.5–587.2) | 8.2 (1.0–589) | 0.24 |
| IL-8 (pg/mL) | 20 (1.98–112.7) | 10.8 (4.8–1127) | 13.2 (2.6–1216) | 0.27 |
| CTC_CC | 4 (0–820) | 0 (0–5) | 0 (0–9) | <0.0001 |
| CTC_CS | 8.5 (0–1428) | 0 (0–1) | 0 | <0.0001 |
| PSA (ng/mL) | 18.5 (1–1120) | 8.2 (0.64–38.8) | 0.04 (0.04–1.12) | <0.0001 |
| CRP (ng/mL) | 7.3 (1.8–94.8) | 2.1 (1–26.4) | n.d. | 0.03 |
CD44—cluster of differentiation 44; DKK-1—Dickkopf1; sHER2—soluble human epidermal growth factor receptor 2; IL-6, -8—interleukin-6, -8; CTC_CC—determined with CellCollector®; CTC_CS—determined with the CellSearch® system; PSA—prostate-specific antigen; CRP—C-reactive protein.