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. 2021 Jun 28;10(7):1615. doi: 10.3390/cells10071615

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Regulation of receptor-mediated MCs activation. (A) IgE-FcεRI is the most classical mechanism of MCs activation, which mainly relies on the Lyn-Syk and Fyn pathways to activate MCs. (B) MRGPRX2/B2 is a novel class of G-protein-coupled receptors that can bind to various secretory proteins (mostly cationic peptides) to activate MCs. (C) P2X7 is an ATP-gated ion channel that is highly expressed in colonic MCs. P2X7 can also be activated by autocrine released ATP, and extracellular ATP can be degraded by E-NPP3 on the membrane.