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. 2021 Jun 22;23(7):792. doi: 10.3390/e23070792
Algorithm 2: CEDA for RMA.
  Input: Training data
  Output: Predictive inferences
  Search for one major factor (a covariate feature-set) for the response feature-set
  based on the MCE roadmap and build a geometry of response manifold by coupling response and major factor feature-sets.
  Partition the entire response manifold into a collective of hypercubes as localities.
  Identify a minor factor based on Shannon entropy within each locality.
  Find localities containing the vector of a major factor pertaining to testing data
  and predict each locality by incorporating information provided by major factor
  and extra information from minor factor.