Figure 1.

Contribution of different cell types to inflammation in adipose tissue. Mature CD11⁺DCs induce differentiation of Th17 under obesity-related insulin resistance and contribute to adipose tissue inflammation. Eosinophils, M2 macrophages, and type 2 innate lymphoid cells regulate metabolic homeostasis in adipose tissue by cytokine expression or dependence upon the γc cytokine chain. Under obesity conditions, M1-like macrophages lead to insulin resistance. Following the adipose increase, macrophage phenotype changed from anti-inflammatory M2 to pro-inflammatory M1 type.