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. 2021 Jun 24;13(7):2178. doi: 10.3390/nu13072178

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of OLE and topotecan combination on the cell viability of IMR-32 and SH-SY5Y cells. (A) MTS assay showing the effects of the single drugs. (B) MTS assay showing the effects of drugs combination. (C) Table showing the combination index (CI) values for each OLE-TOPO combination. Combo 1 = OLE 50 μM plus TOPO 1, 5, and 10 nM; Combo2 = OLE 100 μM plus TOPO 1, 5, and 10; Combo 3 = OLE 200 μM plus TOPO 1, 5, and 10. CI < 1 means synergism. CI > 1 means antagonism. CI = 1 means addiction. (D) Viability assay showing the effects of OLE and TOPO, as single drugs and in combination, on tumor spheroids of IMR-32 cell line. Data are expressed as mean ± SD of three independent experiments (* p < 0.05, ** p < 0.01, *** p < 0.001). CTR: control; OLE: olive leaf extract; TOPO: topotecan; uM: micromolar; nM: nanomolar; OD: optical density; RLU: relative luminescence unit.