Skip to main content
. 2021 Jun 28;13(7):2221. doi: 10.3390/nu13072221

Table 1.

Studies on maternal iron status and child iron status after birth.

Scheme Year Country Country Income Design
(S)
Risk of Bias n Population Back-Ground SF, µg/L Statistics Mother Child
Iron Biomarkers Categories
Based on
Stage Outcome Age
No association
Rios [27] * 1975 USA H Cohort (S) M 26 General NR T-test SF, Fe, TSAT, TIBC SF < 9 µg/L PP SF, TSAT 6 d
Murray [28] * 1978 Niger L Cohort M 49 Famine conditions NA NR Fe, TSAT TSAT < 10% vs. TSAT > 60% PP SF, TSAT 6 m
Kilbride [29] * 2000 Jordan U-M Case control (S) H 195 Refugees 15.2 ‡ T-test SF, Fe, TSAT, (TIBC) Anemia, SF < 12 µg/L PP SF 3, 6, 9, 12 m
Poyrazoğlu [30] * 2011 Turkey U-M Cohort (S) M 92 General 33 ‡ ANOVA SF, Fe, TSAT, TIBC Anemia and (S) II, PP SF, TSAT 3, 6, 12 m
Hanieh [31] * 2013 Vietnam L-M Clinical trial (S) L 1168 General 28.4 § MLR SF, (sTfR, sTfR/SF) (S), SF < 15 µg/L III SF 6 m
Kulik [32] * 2016 Poland H Cohort (S) M 44 General 22 ‡ corr SF, sTfR SF < 15 µg/L PP SF 3 d
Matias [33] * 2018 Bangladesh L-M Clinical trial (S) L 1117 General NR MLR SF, sTfR SF < 12 µg/L III SF 6 m
Positive association
Puolakka [34] * 1980 Finland H Cohort (S) H 47 General NR MWU SF (Fe, TF, TSAT, TIBC) SF < 50 µg/L PP SF 6 m
Milman [35] * 1987 Denmark H Cohort (S) M 56 General 21 † MWU SF (Fe, TF, TSAT) SF < 15 µg/L PP SF 5 d
Morton [36] 1988 UK H Cohort (S) M 51 General NR T-test SF SF < 10 µg/L III SF 6 m
Preziosi [37] * 1997 Niger L Clinical trial (S) M 197 General NR T-test SF (Fe, TSAT) SF < 12 µg/L II, PP SF (Fe, TSAT) 3, 6 m
Liu [38] * 2015 China U-M Cohort L 140 General 19.9 ‡ T-test SF, sTfR Anemia III sTfR (SF) 6 m
(42 d, 4 m)
Santos [39] * 2018 China U-M Clinical trial (S) L 1194 General NR MLR SF, sTfR II, III SF, sTfR 9 m
Abioye [40] * 2019 Philippines L-M Nested-cohort (S) L 359 Women with schistosomiasis and anemia 13.4 ‡ MLR SF, (sTfR) SF < 12 µg/L III SF, (sTfR) 6 m (12 m)
Shukla [41] * 2019 India L-M Cohort L 163 General 62.6 ‡ T-test, corr SF Anemia PP SF 14 wk

Country income according to World Bank classification (https://datahelpdesk.worldbank.org/knowledgebase/articles/906519 accessed on 20 July 2020 ); corr, correlation; d, Days; I, II, III, gestational trimester; H, high; L, low; L-M, lower-middle; U-M, upper-middle; MWU, Mann–Whitney U-test; M, medium; m, months; MLR, multiple linear regression; NA, not applicable; PP, peri-partum; SF, serum ferritin represents reported (or calculated); sTfR, soluble transferrin receptor; (S), maternal iron supplementation, TF, transferrin; TSAT, transferrin saturation; TIBC, total iron binding capacity; wk, week; y, year. * Studies reporting multiple outcomes; †, median; ‡, mean; §, geometric mean; values in the total study population. Studies are grouped by the direction of the association between maternal iron status and child hemoglobin.