Figure 3.

The function of diamine oxidase (DAO) in the enterocyte. The red drop with H shows the histamine released from food. The histamine passes through the enterocyte into the circulation. The DAO enzyme on the basolateral membrane creates a barrier, and the histamine obtained from the food is metabolized (the red drop with H with a green contour). DAO activity is directly/indirectly dependent on internal and external factors such as the polymorphisms of the AOC1 gene, the physiological status of the organism, alcohol, other biogenic amines and medication intake. AOC1—amine oxidase copper containing 1 gene.