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| Group | Evaluation Parameter | Week 0 | Week 4 | Week 8 | Week 12 |
|---|---|---|---|---|---|
| Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | ||
| HA | Wrinkle | 192 ± 38.0 | 187 ± 38.8 | 188 ± 38.7 | 184 ± 39.2 ** |
| Placebo | Wrinkle | 197 ± 42.6 | 202 ± 41.2 | 206 ± 37.4 | 204 ± 41.9 |
** indicates p < 0.01 (Dunnett’s test), compared with week 0. SD, standard deviation; and HA, hyaluronan.
