Table 2.
Association of the Inflammatory Score of the Diet (ISD) with incidence of Crohn’s disease and ulcerative colitis.
| ISD Tertiles a | 1-SD Increment in ISD (Continuous) | |||||
|---|---|---|---|---|---|---|
| Tertile 1 | Tertile 2 | Tertile 3 | ||||
| HR (95% CI) | HR (95% CI) | HR (95% CI) | P-Trend | HR (95% CI) | P-Trend | |
| Crohn’s disease | ||||||
| No. of cases/person-years | 6/225,930 | 13/226,335 | 13/222,283 | |||
| Model 1 b | 0.44 (0.15–1.27) |
1.00 (0.48–2.23) |
1 (ref.) | 0.142 | 1.42 (0.94–2.14) |
0.098 |
| Model 2 c | 0.32 (0.10–1.05) |
0.87 (0.38–2.01) |
1 (ref.) | 0.067 | 1.71 (1.05–2.80) |
0.031 |
| Ulcerative colitis | ||||||
| No. of cases/person-years | 23/225,930 | 19/226,335 | 15/222,283 | |||
| Model 1 b | 1.48 (0.71–3.06) |
1.27 (0.63–2.55) |
1 (ref.) | 0.297 | 0.89 (0.66–1.19) |
0.436 |
| Model 2 c | 1.49 (0.66–3.34) |
1.27 (0.62–2.60) |
1 (ref.) | 0.340 | 0.89 (0.63–1.26) |
0.515 |
Abbreviations: HR, hazard ratio; CI, confidence interval; SD, standard deviation; Ref, reference category. a First, second, and third Inflammatory Score of the Diet tertile ranges were −6.08 to −0.67, −0.67 to 1.29, and 1.29 to 4.98, respectively. b Model 1 is a Cox proportional hazards regression model stratified by centre and adjusted for age (as time scale) and sex. c Model 2: Model 1 + energy intake (continuous).