Table 2.

Summary of glutenases used in enzyme therapy and classified according to origin of isolation, producer organism, and catalytic mechanism. ND, not determined.

Source of Enzymes	Peptidase Type	Organism	Isolated Enzyme	References
Bacterial peptidases	Prolyl endopeptidase	S. capsulata	SC-PEP	[68]
		M. xanthus	MX-PEP	[65]
		F.meningosepticum	FM-PEP	[66]
		Chryseobacterium taeanense	PEP 2RA3	[109]
	Subtilisin	Rothia aeria	ND	[112]
		R. mucilaginosa	Sub-A	[112]
		Bacillus licheniformis	ND	[113]
	Pseudolysin	Pseudomonas aeruginosa	lasB	[114]
	Thermolysin	Bacillus thermoproteolyticus	ND	[113]
	Serine peptidase	Bacillus tequilensis	ND	[115]
	ND	Bacillus spp GS 188	ND	[116]
	Serine carboxyl peptidase	Actinoallomurus A8	E40	[117]
Fungal peptidases	Prolyl endopeptidase	A. niger	AN-PEP	[72]
	Aspergillopepsin	A. niger	ASP	[118]
	Exopeptidase	Aspergillus oryzae	AO-DPP-IV	[119]
Plant peptidases	Cysteine endopeptidase	H. vulgare	EP-B2	[120]
		Carica papaya	Caricain	[121]
		Triticum aestivum	Triticain-α	[122]
		H. vulgare	HvPap-6 CysProt	[123]
Insect peptidases	Prolyl peptidase	Rhizopertha dominica	ND	[123]
	Prolidase	Tenebrio molitor	ND	[124]
Human peptidases	Elastase	Homo sapiens	CEL3B	[22]
		Homo sapiens	CEL2A	[22]
	Carboxypeptidase	Homo sapiens	CBPA1	[22]