Table 3.
Adjusted odds ratio and 95% confidence intervals for metabolic syndrome and various metabolic-related parameters by innate immunity status.
| L-WBC+L-CRP (n = 25,604) |
H-WBC+L-CRP (n = 13,880) |
L-WBC+H-CRP (n = 464) |
H-WBC+H-CRP (n = 820) |
|
|---|---|---|---|---|
| Age (≥55 years) | 1 | 0.90 (0.86–0.95) *** | 1.53 (1.23–1.89) *** | 1.21(1.03–1.42) * |
| Gender (Female) | 1 | 0.74 (0.62–0.87) * | 0.09 (0.01–0.70) * | 1.09 (0.70–1.70) |
| Metabolic syndrome (Yes) | 1 | 1.75 (1.64–1.88) *** |
1.37 (1.05–1.81) |
1.86 (1.54–2.24) ** |
| BMI (≥25 kg/m2) | 1 | 1.49 (1.42–1.56) *** |
1.57 (1.29–1.91) *** |
1.87 (1.62–2.17) *** |
| Waist circumference (>90 cm for men; >85 cm for women) | 1 | 1.15 (1.07–1.23) * |
1.09 (0.81–1.46) |
1.03 (0.82–1.29) |
| Plasma glucose (>126 mg/dL) | 1 | 1.94 (1.80–2.09) *** |
1.74 (1.32–2.01) *** |
2.6 (2.15–3.14) *** |
| HbA1c (>7.5% ) | 1 | 2.56 (2.20–2.96) *** | 2.87 (1.80–4.58) *** | 4.72(3.52–6.33) *** |
| Serum total cholesterol (>240 mg/dL) | 1 | 1.26 (1.19–1.32) *** |
0.89 (0.71–1.13) |
1 (0.84–1.19) |
| Serum HDL (40 for men, 50 mg/dL for women) | 1 | 1.3 1.24–1.37) *** |
1.37 (1.11–1.69) * |
1.69 (1.45–1.97) *** |
| Serum LDL (>160 mg/dL) | 1 | 1.2 (1.13–1.27) *** |
1.04 (0.81–1.35) |
1.02 (0.84–1.24) |
| Serum TG (>200 mg/dL) | 1 | 1.55 (1.45–1.66) *** |
1 (0.77–1.30) |
0.95 (0.79–1.15) |
| SBP (>140 mmHg) | 1 | 1.15 (1.09–1.22) *** | 0.94(0.75–1.18) | 1.18 (1.01–1.38) * |
| DBP (>90 mmHg) | 1 | 1.30 (1.19–1.43) *** | 0.98(0.69–1.41) | 1.43 (1.14–1.81) ** |
| Serum ALT (>40 IU) | 1 | 1.38 (1.26–1.50) | 1.61 (1.15–2.24) | 1.32 (1.03–1.69) |
| Serum AST (>40 IU) | 1 | 1.24 (1.11–1.39) | 1.49 (0.98–2.27) | 2.12 (1.63–2.77) *** |
| Physical activity | 1 | 0.82 (0.78–0.85) *** | 0.94 (0.77–1.16) | 0.67 (0.57–0.78) *** |
Innate immunity was categorized into four groups: L-WBC+L-CRP, H-WBC+L-CRP, L-WBC+H-CRP, and H-WBC+H-CRP. Their cutoffs were <6.2 × 109/mL for white blood cell counts (L-WBC) and <0.5 mg/dL serum CRP concentrations (L-CRP) for low levels. H-WBC and H-CRP represented their high levels. Values represent the adjusted odds ratio and 95% confidence intervals for the participants with the given criteria in the parenthesis after the parameter in the table. Adjusted for covariates, including age, gender, body mass index (BMI), daily energy intake, income, education, the incidence of arthritis, allergy, asthmas, gastritis, gastric ulcer, gallstone, bronchitis, urethritis, physical activity, alcohol intake, and smoking status. L-WBC+L-CRP was a reference for the association analysis. SBP, systolic blood pressure; DBP, diastolic blood pressure; AST, aspartate aminotransferase; ALT, alanine aminotransferase; TG, triglyceride; eGFR, estimated glomerular filtration rate. Adjusted for covariates, including age, gender, body mass index, daily energy intake.* Significantly different from the L-WBC+L-CRP in logistic regression analysis at p < 0.05, ** at p < 0.01, and *** at p < 0.001.