Figure 3.

(A) AS1411 as a targeting agent in a multifunctional aptamer-based system in which a double stranded (5′-GC-3′ or 3′-GC-5′ base pairs) is used to deliver the doxorubicin [39]. (B) DNA tetrahedra structures (DTNs), formed with four molecules of AS1411 bound [40]. (C) 4-arm DNA/RNA construct, with one of the arms presenting the AS1411 and the remaining constituted by different siRNA strands (anti-AKT, anti-MDM2 and anti-Survivin) [41].