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. 2021 Jul 13;14(7):671. doi: 10.3390/ph14070671

Figure 10.

Figure 10

Schematic representation of DNA stabilized GNPs loaded with drug (Doxorubicin or AZD8055). AS1411 (red line) is conjugated through a dithiolane linker (blue). The drug is conjugated through a bifunctional linker composed of an anchoring dithiolane moiety (blue) and self-immolative fragment (brown). The release of the drug is triggered by glutathione breaking the disulfide group present in the self-immolative fragment [102].