Table 1.
Results of physiological tests: open field, dark-light box, elevated plus-maze (EPM), string test.
| Test | Open Field | |||||
|---|---|---|---|---|---|---|
| Indicator | Horizontal Activity (s) | Time in the Center (s) | Entering in the Center (Number) | Rearing (Number) | Hole-Poking (Number) | Grooming (s) |
| Control | 114.62 ± 14.49 | 19.87 ± 7.13 | 5.87 ± 1.78 | 15.25 ± 2.25 | 4.5 ± 0.91 | 10.62 ± 1.44 |
| DMF | 124.00 ± 7.41 | 16.00 ± 4.07 | 5.12 ± 0.67 | 12.75 ± 1.23 | 3.12 ± 0.69 | 9.25 ± 2.61 |
| MB | 83.67 ± 14.27 | 10.5 ± 2.66 | 4.83 ± 1.51 | 14.00 ± 2.67 | 2.66 ± 0.80 | 9.00 ± 3.38 |
| RSV | 90.75 ± 12.89 | 10.66 ± 3.38 | 4.5 ± 1.18 | 7.62 ± 2.09 | 5.5 ± 2.38 | 24.25 ± 4.38* |
| Test | Open Field | Dark-Light Box | EPM | String | ||
| Indicator |
Grooming
(Number) |
Defecation | Time in the Open Compartment (s) | Transition between Compartments (Number) | Time in the Open Arm (s) |
Scores
(Number) |
| Control | 1.75 ± 0.16 | 1.62 ± 0.86 | 235.25 ± 8.64 | 15.75 ± 2.68 | 4.37 ± 1.61 | 2.8 ± 0.33 |
| DMF | 4.12 ± 2.42 | 0.25 ± 0.25 | 253.22 ± 9.16 | 7.67 ± 1.43 * | 8.44 ± 2.53 | 1.82 ± 0.39 |
| MB | 1.5 ± 0.22 | 1.5 ± 0.5 | 231.83 ± 7.50 | 16.83 ± 1.42 | 6.83 ± 2.09 | 3.5 ± 0.43 |
| RSV | 2.75 ± 0.65 | 2.5 ± 1.44 | 64.37 ± 12.64 *** | 8.37 ± 2.14 | 5.75 ± 4.34 | 3.2 ± 0.40 |
The results expressed as means ± SEM. Control n = 8, DMF = 9, MB = 6, RSV = 8. * p < 0.05, *** p < 0.001, comparison of the control group and treated groups using Tukey’s post-hoc test.