Table 3.
Effect estimates for associations of genetic instruments with Hcy and MetS.
| SNP(f) | Chr | Gene | EA | Association with Log-Transformed Hcy a | Association with MetS b | ||||
|---|---|---|---|---|---|---|---|---|---|
| Beta | SE | p-Value | OR | 95% CI | p-Value | ||||
| rs12567136 | 1 | CLCN6 | A | −0.058 | 0.008 | 3.23 × 10−10 | 0.998 | 0.976,1.020 | 0.867 |
| rs1801133 | 1 | MTHFR | G | −0.039 | 0.005 | 2.74 × 10−17 | 0.949 | 0.850,1.059 | 0.354 |
| rs2336377 | 1 | LOC390997 | G | −0.045 | 0.008 | 1.74 × 10−8 | 1.005 | 0.988,1.022 | 0.577 |
| rs1624230 | 3 | KNG1 | C | −0.027 | 0.005 | 3.81 × 10−8 | 0.998 | 0.981,1.014 | 0.774 |
| rs1836883 | 11 | NOX4 | T | 0.029 | 0.005 | 9.55 × 10−10 | 0.983 | 0.967,0.998 | 0.031 |
EA, effect allele; Chr, chromosome; Hcy, homocysteine; MetS, metabolic syndrome. a Results were derived from observation study of the KARE cohort and adjusted for age, sex, and regional area. b Results were derived from merged data of the HEXA and CAVAS cohorts and were adjusted for age, sex, and study site.