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. 2021 Jul 10;13(7):2365. doi: 10.3390/nu13072365

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Rat femur sections from control group-I showed benign looking bone cortex and trabeculae [arrow] with normal mineralization separated by bone marrow element. (B) Sections from diabetic group-II with osteoporotic changes showing thickening of bone cortex associated with separated bone trabeculae [arrows] containing bone marrow element. (C) Rat femurs from group-III revealed fewer thinning of bone trabeculae [arrows] and some degree of separation seen containing bone marrow elements. (D) Microscopical description of group-IV femurs revealed well-formed bone trabeculae [arrow] with benign looking thickness and mineralization with joined trabeculae separated by bone marrow element.