Table 3.
Data from different efforts to try to overcome the problem of radiolysis with high-activity syntheses of [18F]FE-PE2I. Top: manual experiments with low activity to see how much tBuOH is tolerated in the reaction solvent. Bottom: isolated RCY with either tBuOH added or the reaction time reduced (lines not flushed).
| Solvent | RCC, 2 min | RCC, 5 min | RCC, 10 min | RCC, 20 min |
|---|---|---|---|---|
| DMSO, 10% tBuOH | 8.5% | 26.8% | 30.4% | 30.8% |
| DMSO, 5% tBuOH | 13.6% | 36.5% | 42.1% | 46.8% |
| DMSO, 2% tBuOH | 37.9% | 75.6% | 77.4% | 83.8% |
| Results of full synthesis | DMSO, 2% tBuOH, 5 min reaction time | DMSO, 2 min reaction time | DMSO, 3.5 min reaction time | DMSO, 5 min reaction time |
| Isolated RCY (45-GBq starting activity) | 32.8% | 32.0% | - | 34.8% |
| Isolated RCY (140-GBq starting activity) | - | 23.0% | 20.8% | 22.9% |