Hospital admission levels of soluble endothelium–related protective molecules in COVID-19 patients. (a) eNOS, (b) iNOS, and (c) ADM were measured in 21 COVID-19 non-ARDS patients and 68 patients with COVID-19-inflicted ARDS on hospital admission (within 24 h). Two–group comparisons were performed with the non-parametric Mann–Whitney test, * p < 0.05. Data are presented as scatter plots, indicating the median value and 25th to 75th centiles. Dashed line, median value of the whole cohort. ADM = adrenomedullin; ARDS = acute respiratory distress syndrome; eNOS = endothelial nitric oxide synthase; iNOS = inducible nitric oxide synthase.