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. 2021 Jul 19;14(7):695. doi: 10.3390/ph14070695

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Hospital admission levels of serum ACE activity and soluble ACE2 in COVID-19 patients. (a) Serum ACE activity, and (b) soluble ACE2 were measured in 21 COVID-19 non-ARDS patients and 68 patients with COVID-19-inflicted ARDS on hospital admission (within 24 h). Two-group comparisons were performed with the non-parametric Mann–Whitney test, **** p < 0.0001. Data are presented as scatter plots, indicating the median value and 25th to 75th centiles. Dashed line, median value of the whole cohort. ARDS = acute respiratory distress syndrome; sACE = serum angiotensin converting enzyme; sACE2 = soluble angiotensin converting enzyme 2.