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. 2021 Jun 24;14(7):608. doi: 10.3390/ph14070608

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Light-microscopic findings in the study groups. Representative pictures of Masson Trichrome-stained tissue sections from (A–D) Ctrl group (A), DM group (B), enalapril-treated group DM-E (C), and ruxolitinib-treated group DM-R (D). A. Control group showing normal glomerular and tubular structures. B. Glomeruli in the DM group showing increased periglomerular fibrosis (stained in blue) as well as interstitial fibrosis (arrow). C. DM-E group showing improvement of both glomerular and interstitial fibrosis. D. DM-R group showing improvement of both glomerular and tubular changes. Note that glomerular diabetic changes are less evident in the DM-R group than in the DM-E group. Ctrl: control, DM: untreated group, DM-E: enalapril-treated group, DM-R: ruxolitinib-treated group. Original magnifications ×400.