Table 2.
Clinical and Echocardiographic Features in dcSSc Patients versus lcSSc Patients.
|
dcSSc
(n = 27) |
lcSSc
(n = 38) |
p Value | |
| Age, years | 51 ± 14 | 59 ± 14 | 0.02 |
| Female, n (%) | 19 (70) | 35 (92) | 0.01 |
| Body weight, Kg | 60 ± 5 | 57 ± 2 | 0.52 |
| BMI, Kg/m2 | 26 ± 2 | 25 ± 2 | 0.61 |
| Systolic blood pressure, mmHg | 124 ± 22 | 128 ± 21 | 0.44 |
| Diastolic blood pressure, mmHg | 77 ± 8 | 72 ± 7 | 0.62 |
| Hemoglobin, g/dL | 13 ± 0.3 | 15 ± 0.1 | 0.58 |
| Creatinine, mg/dL | 0.98 ± 0.01 | 0.93 ± 0.03 | 0.34 |
| Clinical features | |||
| Disease duration, years | 14 ± 7 | 22 ± 12 | 0.005 |
| PAH, n (%) | 10 (37) | 12 (31) | 0.25 |
| ILD on HRCT, n (%) | 12(44) | 25 (66) | 0.01 |
| Digital ulcers, n (%) | 17 (62) | 22 (58) | 0.83 |
| Treatment, n (%) | |||
| Prostanoid ev | 7 (26) | 5 (13) | 0.21 |
| ET-1 inibithors | 9 (33) | 13 (34) | 0.44 |
| Immunosuppressants | 8 (29) | 22 (58) | 0.008 |
| Echocardiographic measurements | |||
| LVEDD, mm | 46 ± 0.6 | 44 ± 0.5 | 0.07 |
| IVS thickness, mm | 10 ± 0.2 | 12 ± 0.2 | 0.46 |
| PW thickness, mm | 10 ± 0.2 | 12 ± 0.3 | 0.83 |
| LV mass, g | 148 ± 51 | 166 ± 71 | 0.54 |
| LVEDV, mL | 101 ± 29 | 82 ± 21 | 0.004 |
| LVESV, mL | 39 ± 12 | 29 ± 9 | 0.001 |
| SV, mL | 62 ± 20 | 52 ± 13 | 0.03 |
| LVEF (%) | 60 ± 6 | 64 ± 5 | 0.01 |
| Aorta, mm | 29 ± 0.4 | 30 ± 0.3 | 0.12 |
| Left atrium, mm | 48 ± 0.8 | 50 ± 0.9 | 0.50 |
| RVEDD, cm2 | 19.9 ± 5 | 18.3 ± 5 | 0.32 |
| TAPSE, cm | 2.24 ± 0.5 | 2.30 ± 0.5 | 0.65 |
| Peak E velocity, cm/s | 0.90 ± 0.2 | 0.84 ± 0.2 | 0.53 |
| Peak A velocity, cm/s | 0.81 ± 0.2 | 0.78 ± 0.2 | 0.53 |
| DT, ms | 180 ± 54 | 211 ± 61 | 0.38 |
| E/A ratio | 1.19 ± 0.3 | 1.11 ± 0.2 | 0.44 |
| E/e’ ratio | 8.6 ± 2 | 10.7 ± 4 | 0.07 |
| PAP, mmHg | 32 ± 3 | 34 ± 3 | 0.75 |
| Pressure-volume curve relationships | |||
| End-diastolic elastance, mmHg/mL | 0.17 (0.13–0.22) | 0.23 (0.19–0.28) | 0.03 |
| Arterial elastance, mmHg/mL | 1.83 (1.53–2.20) | 2.21 (1.88–2.73) | 0.01 |
| End-systolic elastance, mmHg/mL | 2.90 (2.22–3.56) | 4.06 (3.12–5.49) | 0.001 |
| Ventricular-arterial coupling | 0.69 (0.52–0.74) | 0.52 (0.45–0.65) | 0.02 |
| Stroke work, mmHg·mL | 6284 (4045–8748) | 5805 (4680–8748 | 0.25 |
| Potential energy, mmHg·mL | 1863 (1493–2973) | 1552 (1215–2268 | 0.01 |
| Pressure-volume area, mmHg·mL | 8008 (5487–11,522) | 7357 (6138–11,016 | 0.12 |
| LV efficiency, % | 74 (72–78) | 79 (76–81) | 0.02 |
Abbreviations as in Table 1. Values are mean ± SD or median (IQR).